Effect of 4-Hydroxypyrazolo [3, 4-d] pyrimidine on Uricase Activity
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منابع مشابه
Effects of Allopurinol [4-Hydroxypyrazolo(3,4-d)Pyrimidine] on the Metabolism of Allantoin in Soybean Plants.
Some studies on the effects of xanthine oxidase inhibitor allopurinol [4-hydroxypyrazolo(3,4-d)pyrimidine] on allantoin metabolism of soybean plants (Glycine max cv. Tamanishiki) are reported. Soybean seedlings, aseptically germinated for 96 hours on agar containing 1 millimolar allopurinol, contained only slight amounts of allantoin, allantoic acid, and urea as compared with controls. Analysis...
متن کاملEffect of 4-hydroxypyrazolo (3,4-d) pyrimidine (allopurinol) on postirradiation cerebral blood flow: implications of free radical involvement.
In an attempt to elucidate mechanisms underlying the irradiation-induced decrease in regional cerebral blood flow (rCBF) in primates, hippocampal and hypothalamic blood flows of rhesus monkeys were measured by hydrogen clearance, before and after exposure to 100 Gy, whole body, gamma irradiation. Systemic blood pressures were monitored simultaneously. Compared to control animals, the irradiated...
متن کامل4-hydroxypyrazolo (3,4-d) Pyrimidine (hpp) in the Treatment of Gout: Preliminary Observations.
4-hydroxypyrazolo (3,4-d) pyrimidine (B.W. 56-158: HPP) is a potent inhibitor of the enzyme xanthine oxidase. It was first used in the treatment of leukaemia to suppress the oxidation of 6-mercaptopurine to the therapeutically inert metabolite 6-thiouric acid, and the observation that it lowered the concentration of uric acid in serum and urine has led to its use in gout (Rundles, Wyngaarden, H...
متن کاملStudies on 4-aminopyrazolo(3, 4-d)pyrimidine: growth inhibition and relief in Neurospora crassa.
An analogue of adenine, 4-aminopyrazolo(3,4d)pyrimidine (4-APP), has recently been shown to be a potential antineoplastic agent. Skipper, Robins, and Thomson (1955) demonstrated that the growth of an adenocarcinoma and two leukemias of the mouse was inhibited or retarded by the administration of 4-APP. Hsu, Robins and Cheng (1956) showed that 4-aminopyrazolo(3,4d)pyrimidine exerts differential ...
متن کامل4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
The pyrazolo-[3,4-d]pyrimidine ring system of the title compound, C12H10N4S, is essentially planar [maximum deviation = 0.025 (1) Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42 (6)°]. In the crystal, mol-ecules are linked via pairs of N-H⋯N hydrogen bonds, forming inversion dimers.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1976
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.96.12_1478